The study confirmed there are certain people more difficult to lose weight. The cause is a gene in its body fat. With the discovery of the gene, prevention and treatment of obesity so it is easier to do. Obese like to enter the gateway to many diseases. In addition to illness at risk of heart and blood vessels, body obesity also have increased risk of suffering from type two diabetes.
Experts from the Peninsula Medical School and Oxford University examined the gene and obesity. For that, they examined data about 40,000 people. In that study they compared the genomes of patients with type two diabetes and healthy people. From there they managed to identify the gene FTO. People with type two diabetes tend to have a particular FTO gene variant, which proved something to do with weight. Variants that make people fat is different from other versions of the FTO gene is caused by a single mutation DNA sequence.
Those who carry one copy of the FTO gene variant obese have 30 percent higher risk of suffering from obesity than those who did not have a copy of the variant gene. Those who have two copies of the gene variant had a 70 percent higher risk of suffering from obesity and on average three kilograms heavier than the same person with no copies of the gene. Prof. Andrew Hattersley from the Peninsula Medical School said the study could explain why two people eat the same food and doing the same sport, but a more difficult to lose weight than others. "So far, we practically always get fat because of greedy and lazy. It all happened because one of our own. In fact, it turns out that obesity has a genetic component," he said.
Genes vulnerable
"This study is important because we get the first evidence of genes susceptible to obesity. Knowledge of the genetic susceptibility to weight gain will give important contributions to prevention and treatment of obesity," said Dr. Sadaf Faroogi of the department of clinical biochemistry, University of Cambridge.
However, the team still do not know exactly what the FTO gene variant works or how to change that influences weight gain. Therefore, they are hoping there will be continued research to get the basic biology of obesity. The research was considered promising in the future given the growing number of people who are overweight. In Europe an estimated one in six white men carrying two copies of the variant gene.
"Obesity is the most challenging public health problem," said Dr. Mark Walport, Director of the Wellcome Trust. "The discovery of the gene provides a new slat to understand how a person seem more prone to weight gain than others," he added.
Main button
Meanwhile, other studies have found a gene that has to do with diabetes and cholesterol proved to be a master switch or master switch that controls other genes that are found in the fat in our bodies. In a study has been published in the journal Nature Genetics, researchers from the UK said that because fat plays an important role in our vulnerability exposed metabolic diseases, such as diabetes, obesity, and heart, the primary key genes that could be prime targets for treatment.
"This research is the first large study that opened just how small changes in one gene regulators could impact on other genes," says Tim Spector of King's College London who led the study involving more than 20,000 genes in fat samples from 800 volunteers.
The researchers identified the gene by KLF14 name. The gene was known to have ties with type two diabetes and cholesterol. However, they do not yet know what role these genes play. "KLF 14 seems to act as a master switch controlling the process of linking behavioral changes in muscle fat face clan liver disorders that cause diabetes and other diseases," said Mark McCarthy of Oxford University who participated in the study
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